Your lab's advantage in a new era of NMR diagnostics
The first FDA cleared clinical analyzer based on nuclear magnetic resonance (NMR) technology, Vantera®, combines proprietary signal processing algorithms and NMR spectroscopic detection into a clinical analyzer to identify and quantify concentrations of lipoproteins and, potentially, small molecule metabolites. NMR detectors, or spectrometers, analyze blood plasma or serum samples by subjecting it to a short pulse of radio frequency energy within a strong magnetic field. Each lipoprotein particle within a given diameter range simultaneously emits a distinctive radio frequency signal, similar to distinctive ringing sounds for bells of different sizes. The amplitude or “volume”, of the NMR signal is directly proportional to the concentration of the particle subclass of lipoprotein particles emitting the signal. Our proprietary software then collects, records and analyzes the composite signals emitted by all of the particles in the sample in real time and separates the signals into distinct subclasses. Within minutes, we are able to quantify multiple subclasses of lipoprotein particles.
The Vantera® Clinical Analyzer based on NMR offers the following advantages over conventional methods of quantifying lipoproteins and small molecule metabolites:
- Information-rich detection. NMR can analyze lipoproteins as well as potentially hundreds of small molecule metabolites.
- Processing efficiency. NMR technology does not require physical separation of the lipoprotein particles and does not require chemical reagents in order to evaluate a sample.
- Sample indifference. NMR technology may be used to analyze multiple sample types, including plasma and serum.
- Throughput. Simultaneous lipoprotein and metabolite quantification from a rapid NMR measurement makes the Vantera Clinical Analyzer extremely efficient with high throughput capabilities.